Table of Contents Table Of Content Top Reasons Why You Might Not Be Losing Weight on Semaglutide 1. Inadequate Dosage or Low Dosage or Incorrect Dosage 2. You’re Looking for Drastic Change Too Quickly 3. Insufficient Dietary Changes 4. Lack of Physical Activity Your Exercise Routine May Need Some Adjustments 5. Underlying Health Conditions 6. Medication Interactions 7. Psychological Factors 8. Not Sticking to Dietary Changes 9. You’ve Hit a Plateau 10. Administration Issues 11. Constipation Issues 12. Stay Hydrated 13. You May Need a Higher Dose 14. You’re Not Eating Enough Protein Feeling Stuck? Let’s Turn Things Around Together Expert Answers to Your Queries You’ve started Semaglutide, hoping it would be the answer to your weight loss struggles. But here you are, still staring at the same number on the scale. It’s frustrating, and you’re wondering what’s going wrong. You’re not alone—many people face the same issue. The truth is, there are specific reasons why Semaglutide might not be working for you, and they can vary, and they might surprise you. It could be something as simple as not sticking to the dietary changes that need to go hand-in-hand with the medication. There’s also the possibility of issues with how you’re administering the medication. But that’s just the beginning. There are other factors—like hydration, protein intake, or even the dose you’re on—that might be the silent culprits behind your stalled progress.  Want to know what else could be holding you back? Read on to uncover reasons that could be sabotaging your dreams of shedding pounds and finally feeling fit. Top Reasons Why You Might Not Be Losing Weight on Semaglutide It’s easy to focus on the numbers on the scale, but weight loss isn’t always about what you see there. Sometimes, even when the scale doesn’t move, your body is changing in other ways.  Pay attention to how your clothes fit. You might see only a small drop in weight, but if your clothes fit better or your body looks different, you’re making progress.  Have you noticed changes like this? If not, there might be other reasons why Semaglutide isn’t giving you the results you want. Let’s explore some of the top reasons that could be holding you back. 1. Inadequate Dosage or Low Dosage or Incorrect Dosage The effectiveness of Semaglutide for weight loss depends heavily on getting the right dosage. If the dosage is too low, it might not produce the results you’re looking for. If it’s not administered correctly, it could lead to disappointing outcomes. It’s important to follow your healthcare provider’s guidance on the dosage because they adjust it based on how your body responds. If you think your dosage isn’t right, talk to your provider—they can help you figure out if adjustments are needed to see better results. 2. You’re Looking for Drastic Change Too Quickly Weight loss with Semaglutide doesn’t happen overnight. It’s normal to want quick results, but your body needs time to adjust. In the first few weeks, changes might not be visible on the scale, and that’s okay. Your body could be going through other changes that aren’t immediately reflected in your weight. Give it at least another month before you assess how well it’s working. Patience is important—sustainable weight loss takes time. 3. Insufficient Dietary Changes Semaglutide helps manage appetite, but diet plays a huge role in its success. If your eating habits haven’t changed, you might not see the weight loss you expect. Hidden calories, like those in snacks or drinks, can add up and stall progress. Are you tracking your daily calories? You should be eating about 500 calories less than your Total Daily Energy Expenditure (TDEE) for effective weight loss.  You can use tools like a TDEE calculator to figure out your ideal intake. 4. Lack of Physical Activity Exercise is key to making Semaglutide work better for weight loss. While Semaglutide helps control your appetite, regular physical activity boosts fat loss and improves your overall health.  You should aim for at least 150 minutes of moderate exercise each week [6], along with strength training on two days.  You can use fitness apps like MyFitnessPal or Fitbit, which will help you track your activity and stay on track. Your Exercise Routine May Need Some Adjustments If you’re working out but not seeing results, your routine might need a change. Cardio alone might not be enough. Adding strength training can help because muscle burns more calories than fat. A mix of aerobic exercises (like walking or cycling) and strength training (like weight lifting) can make a big difference. Try using workout apps for a personalized plan or consider consulting a fitness trainer. 5. Underlying Health Conditions Some health conditions can make it hard to lose weight, even with Semaglutide. Conditions like hypothyroidism can slow down your metabolism [5], and hormonal imbalances can interfere with weight loss. If you think an underlying condition might be affecting you, talk to your healthcare provider. They may suggest blood tests to check for thyroid function or hormone levels. Your gut health also matters. Studies show that a healthy gut can support weight loss by improving digestion and nutrient absorption. Poor gut health can lead to weight gain or make it harder to lose weight. Adding probiotics, like those found in no-sugar-added kefir or yogurt, can improve gut health and might help Semaglutide work better.  6. Medication Interactions Certain drugs, such as corticosteroids, antipsychotics, and even some diabetes medications, can counteract the effects of Semaglutide, making it harder to lose weight.  For example, corticosteroids can lead to weight gain by increasing appetite and altering metabolism [4]. If you’re taking other medications, it’s important to discuss these with your healthcare provider to ensure there are no adverse interactions. They might adjust your treatment plan or recommend alternatives that are more compatible with Semaglutide. If you’re taking other medications, talk to your healthcare provider. They can check for interactions and might adjust your treatment.  You can also use online tools like Drugs.com’s Interaction