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Can Weight Loss Drugs Really Help with Addiction?

Can Weight Loss Drugs Really Help with Addiction?

Introduction Who would’ve thought that the same drugs helping people shed pounds might also kick some bad habits out the window? Yep, we’re talking about weight loss meds like Semaglutide and Tirzepatide potentially playing a role in addiction treatment. Sounds wild, right? But there’s some serious science behind this, and researchers are excited about where it might lead. It’s not every day that a medication designed for one thing ends up having the potential to help with something entirely different, but that’s exactly what’s happening here. The Surprising Link Between Weight Loss and Addiction So, what’s the connection? It all starts with a hormone called GLP-1 (glucagon-like peptide-1). Normally, when you eat, your pancreas pumps out GLP-1, which tells your brain, “Hey, you’re full. Put down the spoon!” This signaling is a critical part of keeping our appetite in check. But in people with conditions like obesity or diabetes, this signaling can get a little out of sync, leading to overeating. Your body basically forgets to tell you when you’ve had enough. That’s where weight loss drugs like Semaglutide come in. These drugs mimic GLP-1 to help get those hunger signals back on track. They act like GLP-1’s stunt double, making sure the message gets through loud and clear: Stop eating, you’re good! But here’s where things get interesting—GLP-1 doesn’t just mess with your appetite. It turns out, it also has a hand in how your brain’s reward system works. This is the same system that lights up when you do something that feels good, like eating your favorite food, winning a game, or, unfortunately, using addictive substances like nicotine, alcohol, or drugs. Researchers started to wonder—if GLP-1 can help curb food cravings, could it also help with other cravings? And that’s when things started to get interesting. How Do These Medications Mess with Your Brain? Let’s break it down a bit. The brain’s reward system is all about dopamine, the chemical that makes you feel good. Imagine dopamine as your brain’s way of giving you a high five whenever you do something that’s good for survival, like eating a meal or spending time with loved ones. It’s like a little internal cheerleader, encouraging you to keep doing things that are good for you. Normally, dopamine is great—it makes sure you keep doing things that are important for survival, like eating or socializing. But here’s the catch: addictive substances can hijack this system, making you crave more and more to get that same dopamine hit. It’s like your brain gets stuck in a loop, constantly seeking out the next hit, whether that’s from food, cigarettes, alcohol, or drugs. That’s basically how addiction takes hold. Now, GLP-1 agonists (fancy term for drugs like Semaglutide that mimic GLP-1) might help by reducing how much dopamine your brain pumps out in response to those addictive substances. In simple terms, these drugs could make your brain less excited about nicotine, alcohol, or even opioids, potentially helping to break the cycle of addiction. Imagine if your brain just stopped caring so much about that next cigarette or drink—it could be a game-changer. What’s the Evidence? So, is this all just a theory, or is there some proof? Researchers are on it! In one of the biggest studies so far, scientists tested another GLP-1 drug called exenatide on people with alcohol use disorder. The cool part? When these folks took exenatide, their brains didn’t light up as much when they saw booze, which suggests they weren’t craving it as much. But here’s the twist—this effect was strongest in people who were also dealing with obesity. That’s got researchers scratching their heads. Why would weight influence how well these drugs curb addiction? No one’s totally sure yet, but it could mean that GLP-1 drugs work better for some people than others. Or maybe there’s something special about how obesity and addiction interact. Either way, it’s got scientists eager to dig deeper. And that’s not all—there are studies underway looking at how these drugs might help with other addictions, like smoking and even opioid use. The possibilities are pretty exciting, but there’s still a lot we don’t know. The Safety Question Of course, nothing’s ever that simple, especially when it comes to meds. While GLP-1 drugs are generally safe for people using them to manage weight or diabetes, there are some concerns about using them to treat addiction. For starters, people who are malnourished or have certain health issues might not react well to these drugs. Imagine someone who’s struggling with a drug addiction—they might already be in poor health, and adding a new medication into the mix could have some unexpected effects. Plus, if GLP-1 drugs reduce dopamine too much, there’s a chance they could mess with your mood or motivation. Imagine feeling so “meh” that you lose interest in stuff you used to love—nobody wants that! It’s all about balance, and right now, we don’t know enough about how these drugs might affect people with different health backgrounds or levels of addiction. And let’s not forget about the side effects. Nausea and vomiting are common with these meds, which isn’t exactly fun. If you’re trying to get clean from an addiction, the last thing you need is to feel sick all the time, right? It could be enough to make someone quit the medication altogether, which would be a setback in their recovery journey. A Long Road Ahead So, what’s next? There’s still a lot to figure out. For one, the FDA hasn’t approved GLP-1 drugs for treating addiction yet. And while some researchers are running trials to see how well these drugs work for things like alcohol and opioid addiction, big pharma companies like Novo Nordisk and Eli Lilly are sticking to weight loss and diabetes for now. It’s a bit of a waiting game to see if these drugs really have what it takes to help people struggling with addiction. Even if these drugs do turn out to be a game-changer for addiction,

Can’t get insurance to approve weight loss drugs?

Can’t get insurance to approve weight loss drugs?

If you’ve watched TV or spent any time online lately, you’ve likely seen ads for weight loss drugs. They often highlight the dual benefits of not only shedding pounds but also managing diabetes. The results are undeniable, but there’s one major catch: these drugs come with a steep price tag. And if you’ve tried to get your insurance to cover them, you may have run into some frustrating roadblocks. Up to now, insurers have been reluctant to prescribe them! And in today’s blog, we will discuss the best ways to get your health plan to pay for your prescription and even methods you could use to lower the fees of your medications.  Back in the years, weight loss drugs have sometimes been considered a “lifestyle” or “cosmetic” issue. However, the World Health Organization (WHO) recognizes obesity as a chronic disease. This classification highlights that obesity is a long-term, relapsing condition that requires ongoing management, rather than just being a result of lifestyle choices or temporary weight gain.  Weight Loss Medication  Before we get to the ways to get your health plan to pay for your prescription, we need to understand what weight loss medication we are referring to and who are they geared towards. The category of medication we are talking about are GLP and GLP-1 agonists medication. You may have heard of Semaglutide and Tirzepatide, these are weight loss medications that work by mimicking the effects of a naturally occurring gut hormone.  In short, these are FDA-approved medications that contribute to weight loss up to 15 to 20 percent loss of body weight and both Semaglutide and Tirzepatide are both geared toward people with type 2 diabetes.  You can find more details about Semaglutide and Tirzepatide if you are interested in our website: https://naturopathicweightloss.com/blog/  What you should know It’s true that many employers and insurance plans don’t cover medications specifically for weight loss. You might wonder, though, if having a prescription from a doctor is enough for an insurer to cover the cost? Well, not necessarily, it is not often the only green light. If your doctor prescribes one of these drugs, there’s usually a process to follow. Often, your doctor will need to get prior authorization from the insurance company to cover the medication. This might involve filling out a form or writing a letter. The insurance plan typically wants to proof that you really need the drug. For example, if you have type 2 diabetes and need GLP-1 medication, you might need to show that you have diabetes and that you’ve tried other diabetes medications without success. They might also check if you meet specific criteria, like having a BMI of 30 or higher, or 27 or higher with a related health condition like high blood pressure. Additionally, they sometimes want to see that you’ve tried other weight loss methods, such as a structured program. Now, if your health plan covers GLP or GLP-1 medication, does that mean you’re off the hook for any out-of-pocket costs? It depends on your health plan. Anyone who has had different health plans knows that out-of-pocket costs can vary widely for the same treatment, depending on your employer or insurance provider. Sometimes, you might just have a flat co-pay like you do for many medications, but since these drugs are expensive, employers are cautious about the costs—both for individual patients and the number of people who might need them. Other options? So, if you’ve found out that your employer and insurance don’t cover your medication, does that mean you’re out of luck and won’t get the treatment you need?  Not at all!  There are plenty of rebates and discounts offered by manufacturers that can significantly lower the cost of these drugs—sometimes by over 50%. Other alternatives are prescription rate. “If you have diabetes and you can prove it, you can easily register for a prescription rate and receive discounts There are also other methods knowns as co-pay and co-insurance.  You may not be aware but your insurance plan might offer different ways to share the cost. Instead of having you pay the full price out-of-pocket, your plan could require a co-pay, which is a fixed amount you pay each time you fill the prescription. For example, you might pay a consistent $20 per refill, regardless of the medication’s actual cost.  Alternatively, your plan might involve co-insurance, where you pay a percentage of the medication’s price, such as 20%. This means if semaglutide costs $200, you would pay only $40.  It is understandable that all the methods mentioned can become overwhelming as it may involves contacting your insurance, your doctor and filling documents back and forth.  There are people who prefer turning to “Buy Now, Pay Later” (BNPL) options to help spread out these costs, making it easier to manage. With BNPL, you can break down the price of your medication into smaller, more affordable payments over time. For example, instead of paying $400 upfront for a month’s supply of semaglutide, you might pay $100 every two weeks for two months. This way, you get the medication you need right away, without straining your budget. Many companies offer these kinds of services, and they often don’t charge interest if you make your payments on time. Conclusion  Now the good news: these medications are already approved for treating diabetes and reducing cardiovascular risk, and there are more studies coming out soon that could lead to approvals for other conditions common in people who are obese, like chronic knee pain, osteoarthritis, and sleep apnea. If these new uses get approved, they could end up being covered by insurances.  Finger crossed but it seems that over the next few years, we’re likely to see more of these medications being approved and becoming more accessible through healthcare, even if congress doesn’t act right away. So, it’s a good bet that coverage will expand, and more people will be able to access these treatments.

How Long Does It Take for Semaglutide to Suppress Appetite?

How Long Does It Take for Semaglutide to Suppress Appetite?

Table of Contents Table Of Content What is Semaglutide and How Does It Work? How Long Does It Take for Semaglutide to Work? Factors Affecting How Long It Takes Semaglutide to Work What to Expect During the First Few Weeks of Semaglutide Treatment Precautions FAQ You’ve tried diet after diet, workout after workout, but those cravings just won’t quit. Each time you don’t see results, it feels like another letdown, leaving you wondering if anything will really work. Now, semaglutide offers that hope, but the burning question on your mind is, how long does it take for semaglutide to suppress appetite? When you’re fighting those relentless hunger pangs, each day without relief feels unbearable. But you’re not in this alone, and you’re not without help.  In this blog post, we will share how long semaglutide takes to work, so you can hold on to that hope just a little longer, knowing that change is on the horizon. What is Semaglutide and How Does It Work? Semaglutide is a medication initially developed to manage type 2 diabetes, but it has also become a powerful tool for weight management. It belongs to a class of drugs called GLP-1 receptor agonists, which mimic the effects of the glucagon-like peptide-1 (GLP-1) hormone naturally produced in your body.  This is how it works: 1. Appetite Suppression:  Semaglutide works by slowing down digestion and sending signals to your brain that make you feel fuller for longer. This action helps reduce hunger and, consequently, your overall calorie intake. By regulating these hunger signals, semaglutide makes it easier to stick to a healthy eating plan. 2. Blood Sugar Control:  Semaglutide also stimulates the pancreas to release more insulin when blood sugar levels are high, helping to lower blood glucose. This dual action is particularly beneficial for individuals with type 2 diabetes, as it not only controls blood sugar but also aids in weight management by reducing appetite. 3. Slows Digestion:  Semaglutide ensures that food is released more slowly from the stomach into the intestines by slowing gastric emptying. This slower digestion helps maintain stable blood sugar levels after meals and contributes to a sustained feeling of fullness, making it easier to manage food portions and resist overeating. How Long Does It Take for Semaglutide to Work? How long does semaglutide take to work can vary depending on several factors, but here’s what most people can generally expect: 1. First Few Days to the First Week:  Some people notice subtle changes within the first week. You might start to feel a slight reduction in hunger and find it a bit easier to avoid snacking between meals. However, don’t be discouraged if you don’t feel a significant difference right away—this initial period is just the beginning. 2. Weeks 2 to 4:  By the second to fourth week, semaglutide typically starts to have a more noticeable effect on your appetite. Many users report feeling fuller after meals and experiencing fewer cravings. This is when you might start to see the real benefits of the medication, making it easier to stick to your dietary goals and reduce your calorie intake. Tip: For even better results, try combining semaglutide with a naturopathic weight loss plan.  If you’re curious about how GLP-1 agonists like semaglutide can be part of a broader naturopathic strategy, check out this detailed guide on how GLP-1 agonists support naturopathic weight loss. It’s full of helpful insights. 3. Weeks 5 to 12:  As you continue with semaglutide, its appetite-suppressing effects generally become more consistent. Around this time, you might notice a more significant reduction in hunger, leading to steady weight loss. For some, the effects might intensify as the dosage is gradually increased, in line with your healthcare provider’s recommendations. 4. After 12 Weeks:  For most users, the long-term benefits of semaglutide begin to solidify after 12 weeks of consistent use. Appetite suppression remains steady, supporting ongoing weight loss and helping to manage food intake more effectively.  Research has shown that continuation with semaglutide led to ongoing weight loss over the following 48 weeks, resulting in an average of 17.4% reduction in body weight from baseline. [2] Factors Affecting How Long It Takes Semaglutide to Work The timeline for semaglutide to start working can vary significantly from person to person due to several key factors.  1. Individual Metabolic Rate: Your metabolism plays a crucial role in how quickly you notice the effects of semaglutide. Individuals with a faster metabolic rate may experience the appetite-suppressing effects sooner than those with a slower metabolism. This variability also impacts how fast semaglutide works for different people, as factors like age, genetics, and overall health influence metabolic speed. 2. Lifestyle Choices: Your diet and exercise habits significantly impact how well and how quickly semaglutide works. Combining semaglutide with a balanced diet and regular physical activity can enhance its effectiveness, leading to faster and more pronounced results. Conversely, a sedentary lifestyle or poor dietary choices can delay how fast semaglutide works and make it harder to achieve the desired benefits. 3. Adherence to Prescribed Dosage: The medication typically starts at a lower dose to minimize side effects and is gradually increased. Adults generally begin with 0.25 milligrams (mg) [3] injected under the skin once a week for the first 4 weeks. Your doctor may increase your dose as needed, but the usual maximum dose is 2 mg once a week.  Note that missing doses or not following the prescribed schedule can delay the onset of its appetite-suppressing effects. 4. Interaction with Other Medications: If you are taking other medications or have underlying medical conditions, these can interact with semaglutide and affect how quickly it works. Some drugs may slow down the absorption or effectiveness of semaglutide, while others may enhance its effects.  5. Working with a Healthcare Provider: Regular check-ins with your healthcare provider are crucial to monitor your progress and make any necessary adjustments to your treatment. Your provider can help optimize your dosage and address any side effects, ensuring that semaglutide works

Tirzepatide in treating obstructive sleep apnea and obesity

Tirzepatide in treating obstructive sleep apnea and obesity

Table of Contents Table Of Contents What is Sleep Apnea? Sleep Apnea In-depth Sleep Study Methods in the Study The Results Adverse Events Limitations Conclusion This is going to be a different type of blog post. Today we will discuss and summarize a recent paper published on June 21, 2024, in The New England Journal of Medicine exploring Tirzepatide for treating sleep apnea and obesity. Here we go! Approximately 39 million US adults have obstructive sleep apnea, and 936 million adults worldwide are estimated to have mild to severe obstructive sleep apnea. What is sleep apnea? Obstructive sleep apnea is a common condition where the airway gets blocked during sleep, causing breathing to stop and start repeatedly. One of the main risk factors for this condition is obesity. People who are overweight are more likely to have obstructive sleep apnea because the extra weight can put pressure on the airway and make it more likely to collapse during sleep. Hence it was no surprise, that there is a press release about a study that looked at how Tirzepatide affects sleep apnea. Sleep apnea in-depth Before we get to the findings, let’s learn more about sleep apnea. There are two types of sleep apnea. The first type is obstructive sleep apnea, which happens when the upper airway gets blocked during sleep. This blockage interferes with breathing and can cause a person to stop breathing for short periods while asleep. The second type is central sleep apnea. This occurs when the brain doesn’t send the right signals to the muscles that control breathing. As a result, the muscles and nerves aren’t activated enough for breathing, leading to pauses in airflow during sleep. The reason we care about sleep apnea is because, if left untreated, it can lead to many serious health problems. These include insulin resistance, type 2 diabetes, high blood pressure, abnormal cholesterol levels, high blood sugar, stroke, kidney disease, sexual dysfunction, and coronary artery diseases like heart failure. Essentially, untreated sleep apnea can cause a wide range of medical issues. Additionally, several health conditions can increase the risk of developing sleep apnea, such as hypothyroidism, cleft lip or cleft palate, heart disease, kidney disease, large tonsils, obesity or higher body weight, and even menopause. These conditions can either cause sleep apnea or make it worse. Now, how do you know if you have sleep apnea? Some of the most common symptoms include excessive daytime sleepiness, where you go to sleep, wake up, and still feel unrested. You might also experience loud snoring. Another symptom is observed episodes where you stop breathing while sleeping. You might suddenly start breathing again with a gasp, or someone may need to nudge you awake to resume breathing. People with sleep apnea might also wake up gasping or coughing. Additionally, some wake up with a dry mouth or sore throat in the morning. Morning headaches are also a common symptom. Sometimes, difficulty controlling blood pressure can be an indicator of sleep apnea. If you have any of these symptoms, it might be worth consulting a healthcare professional to get evaluated for sleep apnea. Sleep study If you think you might have sleep apnea and want to get diagnosed, the first step is to undergo a sleep study. There are several types of sleep studies available. The most common one is done at a sleep clinic, where you stay overnight. During this study, called polysomnography, they place leads on your head to monitor brain activity, and sensors on your chest to check your heart and breathing. They also measure your oxygen levels while you sleep. Another option is a home sleep test, which you can do in your bed. This test doesn’t use as many sensors. Typically, you’ll wear a device like a watch, have a band around your chest, a sensor in your nose to monitor airflow, and a pulse oximeter on your finger to check oxygen levels. This home test is more convenient and often less expensive than the in-clinic study, depending on your insurance. Both types of tests provide valuable information to help diagnose sleep apnea. As we know, Tirzepatide is a once-weekly GIP and GLP-1 receptor agonist known to lead to a 20% reduction in body weight. If you are familiar with Semaglutide, you can think of Tirzepatide as its younger stronger brother. Methods in the study It is an industry-funded study, it was conducted in two phase 3, double-blind, randomized, controlled trials involving adults with moderate-to-severe obstructive sleep apnea and obesity. The participants were assigned to receive either the maximum tolerated dose of Tirzepatide (10 mg or 15 mg) or a placebo for 52 weeks. In terms of the most salient exclusion criteria, type 1 diabetes, type 2 diabetes, a prior or planned surgery, or if they had a self-reported weight loss of more than 5kg in the past 3 months. The intervention was Tirzepatide, which started at a dose of approximately 2 and a half mg once a week and up to 15 mg once a week and to a comparison of placebo. The outcome was change from the baseline in the Apnea-Hypopnea Index (AHI). In brief, the AHI index is essentially how many times a person stops breathing every hour, it’s assessed with a sleep study. So, all the participants in this study had a sleep study done at the beginning and a follow-up sleep study at the end of the trial. The Results Now, let’s dive into the actual results! They recruited 470 adults, and as noted they were randomized to Tirzepatide or placebo. The average age was 50. 30% were women and 73% were white, the average BMI was 39 and the base AHI index was 50 as a point of reference “AHI above 30 is severe” In other words, this was the real deal in terms of sleep apnea. So, what happened? Well, in the group of Tirzepatide, those patients experienced a 25%-point reduction in their AHI index which is remarkable compared to the placebo

How GLP-1 Agonists Support Naturopathic Weight Loss

How GLP-1 Agonists Support Naturopathic Weight Loss

Table of Contents Table Of Content What is Naturopathic Weight Loss? What are GLP-1 Agonists? What is the Link Between Naturopathic Weight Loss and GLP-1? Popular GLP-1 Agonists 1. Tirzepatide Diet Plan 2. Semaglutide Diet Plan Could This Be What You’re Missing? In 2021, 38.4 million Americans—11.6% of the population—were living with diabetes. GLP-1 agonists, like Semaglutide and Tirzepatide, were created to help manage this condition. They’re now being used to help with weight loss too.  If you’re tired of struggling with diets that don’t work, these medications might be worth a look.  In this article, we’ll explore how these medications are incorporated into modern diet plans and what you should know if you’re considering them for your weight loss journey. Read on to see if they could be the solution you need. What is Naturopathic Weight Loss? Naturopathic weight loss is all about using natural ways to help people shed pounds and keep them off. This method combines dietary changes, regular exercise, stress management, and natural supplements.  Instead of depending on medications or surgeries, it highlights the importance of consuming whole foods, staying active, and managing stress for sustainable weight loss. A big part of this approach is taking whole grains, fruits, vegetables, nuts, seeds, and legumes, which together support a healthier lifestyle. What are GLP-1 Agonists? GLP-1 agonists are medications that mimic the action of the Glucagon-like Peptide 1 (GLP-1) Hormone in the body. This hormone is produced in the gut and significantly helps manage blood sugar levels and appetite.  Here’s how they work: Appetite Control — GLP-1 agonists slow down the emptying of the stomach, which prolongs the feeling of fullness after meals. This reduced hunger leads to lower calorie intake, which is essential for weight loss. Blood Sugar Regulation — These medications increase the release of insulin in response to food, helping to manage blood sugar levels more effectively. Stable blood sugar levels are crucial for preventing excessive hunger and energy crashes, which can lead to overeating. Reduced Glucagon Secretion — GLP-1 agonists reduce the secretion of glucagon, a hormone that prevents the liver from releasing too much glucose into the blood. This helps maintain lower blood sugar levels, further aiding in weight control. Dosage info — These medications are typically administered as injections (weekly or daily), though some are available as daily pills. While they are generally effective, side effects like nausea and digestive discomfort may occur but often improve over time. What is the Link Between Naturopathic Weight Loss and GLP-1? The connection between naturopathic weight loss and GLP-1 agonists lies in their complementary approach to managing weight. When GLP-1 agonists are integrated into a naturopathic weight loss plan, they can support the body’s natural processes by helping to control hunger and improve insulin sensitivity. This combination of natural methods and medication can offer a more balanced and effective approach to weight loss, especially for those who struggle with obesity or have related health issues​. Popular GLP-1 Agonists Tirzepatide and Semaglutide are two of the most widely used GLP-1 agonists in weight loss and diabetes management. Tirzepatide is unique because it is a dual agonist and targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual action leads to more significant weight loss compared to Semaglutide. Tirzepatide is also under consideration for FDA approval specifically for weight loss which adds to its growing reputation as a powerful option for obesity management​. Semaglutide, on the other hand, solely targets the GLP-1 receptor. It has been extensively studied and is currently approved for both type 2 diabetes and obesity management. Its long track record provides a solid understanding of its efficacy and makes it a reliable choice for many patients​. Note: Both medications are effective, but Tirzepatide generally offers greater weight loss, though it may also have a higher risk of gastrointestinal side effects like nausea and vomiting.  The choice between these medications should be based on individual health needs, potential side effects, and consultation with a healthcare provider. 1. Tirzepatide Diet Plan Tirzepatide helps reduce body weight by making you feel fuller for longer and curbing your appetite. This reduces the overall calorie intake, making it easier to stick to a diet and achieve sustainable weight loss.  Studies have shown that Tirzepatide can lead to a 20% reduction in body weight in patients, which is higher than what’s typically seen with other weight loss medications like Semaglutide. If Tirzepatide feels right for you, check it out here. You can follow these dietary guidelines to get the most out of Tirzepatide: Focus on vegetables, fruits, lean proteins, and whole grains. These foods help stabilize blood sugar levels and complement Tirzepatide’s appetite-suppressing effects. Include sources like avocados, nuts, and olive oil. These fats contribute to satiety and do not cause significant blood sugar spikes, supporting Tirzepatide’s benefits. Go for complex carbohydrates like brown rice, quinoa, and sweet potatoes. These carbs release sugar slowly and can help prevent blood sugar spikes that can undermine the effects of Tirzepatide. Drink plenty of water to aid digestion and support Tirzepatide’s effectiveness. Proper hydration also helps manage any gastrointestinal side effects. These foods can lead to digestive issues, particularly when combined with Tirzepatide. So, it will be wiser to stick to lighter and less processed options. 2. Semaglutide Diet Plan Semaglutide is a GLP-1 agonist that supports weight loss by reducing appetite, slowing stomach emptying, and helping regulate blood sugar levels. However, It’s essential to pair it with an appropriate diet plan that complements these effects to get the best results from Semaglutide. Semaglutide helps reduce body weight by about 12-13% on average at the highest doses.  You can follow these dietary guidelines to get the most out of Semaglutide: Prioritize a diet rich in vegetables, fruits, lean proteins, and whole grains. These foods help stabilize blood sugar levels and enhance the appetite-suppressing effects of Semaglutide. Add lean meats like chicken, turkey, and fish, as well as plant-based proteins like beans and lentils. Protein helps maintain muscle mass during

Tirzepatide in treating obstructive sleep apnea and obesity

Tirzepatide in treating obstructive sleep apnea and obesity

Table of Contents Table Of Content Sleep apnea in-depth Sleep study Methods in the study The Results Adverse events Limitation Conclusion This is going to be a different type of blog post. Today we will discuss and summarize a recent paper published on June 21, 2024, in The New England Journal of Medicine exploring Tirzepatide for treating sleep apnea and obesity. Here we go! Approximately 39 million US adults have obstructive sleep apnea, and 936 million adults worldwide are estimated to have mild to severe obstructive sleep apnea. What is sleep apnea? Obstructive sleep apnea is a common condition where the airway gets blocked during sleep, causing breathing to stop and start repeatedly. One of the main risk factors for this condition is obesity. People who are overweight are more likely to have obstructive sleep apnea because the extra weight can put pressure on the airway and make it more likely to collapse during sleep. Hence it was no surprise, that there is a press release about a study that looked at how Tirzepatide affects sleep apnea. Sleep apnea in-depth Before we get to the findings, let’s learn more about sleep apnea. There are two types of sleep apnea. The first type is obstructive sleep apnea, which happens when the upper airway gets blocked during sleep. This blockage interferes with breathing and can cause a person to stop breathing for short periods while asleep. The second type is central sleep apnea. This occurs when the brain doesn’t send the right signals to the muscles that control breathing. As a result, the muscles and nerves aren’t activated enough for breathing, leading to pauses in airflow during sleep. The reason we care about sleep apnea is because, if left untreated, it can lead to many serious health problems. These include insulin resistance, type 2 diabetes, high blood pressure, abnormal cholesterol levels, high blood sugar, stroke, kidney disease, sexual dysfunction, and coronary artery diseases like heart failure. Essentially, untreated sleep apnea can cause a wide range of medical issues. Additionally, several health conditions can increase the risk of developing sleep apnea, such as hypothyroidism, cleft lip or cleft palate, heart disease, kidney disease, large tonsils, obesity or higher body weight, and even menopause. These conditions can either cause sleep apnea or make it worse. Now, how do you know if you have sleep apnea? Some of the most common symptoms include excessive daytime sleepiness, where you go to sleep, wake up, and still feel unrested. You might also experience loud snoring. Another symptom is observed episodes where you stop breathing while sleeping. You might suddenly start breathing again with a gasp, or someone may need to nudge you awake to resume breathing. People with sleep apnea might also wake up gasping or coughing. Additionally, some wake up with a dry mouth or sore throat in the morning. Morning headaches are also a common symptom. Sometimes, difficulty controlling blood pressure can be an indicator of sleep apnea. If you have any of these symptoms, it might be worth consulting a healthcare professional to get evaluated for sleep apnea. Sleep study If you think you might have sleep apnea and want to get diagnosed, the first step is to undergo a sleep study. There are several types of sleep studies available. The most common one is done at a sleep clinic, where you stay overnight. During this study, called polysomnography, they place leads on your head to monitor brain activity, and sensors on your chest to check your heart and breathing. They also measure your oxygen levels while you sleep. Another option is a home sleep test, which you can do in your bed. This test doesn’t use as many sensors. Typically, you’ll wear a device like a watch, have a band around your chest, a sensor in your nose to monitor airflow, and a pulse oximeter on your finger to check oxygen levels. This home test is more convenient and often less expensive than the in-clinic study, depending on your insurance. Both types of tests provide valuable information to help diagnose sleep apnea. As we know, Tirzepatide is a once-weekly GIP and GLP-1 receptor agonist known to lead to a 20% reduction in body weight. If you are familiar with Semaglutide, you can think of Tirzepatide as its younger stronger brother. Methods in the study It is an industry-funded study, it was conducted in two phase 3, double-blind, randomized, controlled trials involving adults with moderate-to-severe obstructive sleep apnea and obesity. The participants were assigned to receive either the maximum tolerated dose of Tirzepatide (10 mg or 15 mg) or a placebo for 52 weeks. In terms of the most salient exclusion criteria, type 1 diabetes, type 2 diabetes, a prior or planned surgery, or if they had a self-reported weight loss of more than 5kg in the past 3 months. The intervention was Tirzepatide, which started at a dose of approximately 2 and a half mg once a week and up to 15 mg once a week and to a comparison of placebo. The outcome was change from the baseline in the Apnea-Hypopnea Index (AHI). In brief, the AHI index is essentially how many times a person stops breathing every hour, it’s assessed with a sleep study. So, all the participants in this study had a sleep study done at the beginning and a follow-up sleep study at the end of the trial. The Results Now, let’s dive into the actual results! They recruited 470 adults, and as noted they were randomized to Tirzepatide or placebo. The average age was 50. 30% were women and 73% were white, the average BMI was 39 and the base AHI index was 50 as a point of reference “AHI above 30 is severe” In other words, this was the real deal in terms of sleep apnea. So, what happened? Well, in the group of Tirzepatide, those patients experienced a 25%-point reduction in their AHI index which is remarkable compared to the placebo which was only a

How to Address Common Side Effects of Glp-01s with Naturopathic Supplements?

How to Address Common Side Effects of Glp-01s with Naturopathic Supplements?

Table of Contents Table Of Content Side Effects and Supplements Nausea Diarrhea Multiple Strains of Probiotics Pain in the Abdomen Overall Assistance with Digestion Conclusion Injectable anti-diabetic medications known as glucagon-like peptide-1 (GLP-1) receptor agonists help patients with type 2 diabetes (T2D) achieve better glycemic control and many other atherosclerosis-related metrics. Nonetheless, there might be potential negative consequences from using this relatively new class of medications. Since GLP-1 receptor agonists have been linked to pancreatitis, pancreatic cancer, and thyroid cancer in animal studies and drug database analysis, concerns have been raised about these medications’ impact on pancreatic and thyroid tissue. Nevertheless, a number of meta-analyses were unable to establish a causal relationship between GLP-1 receptor agonists and the emergence of these negative effects. Side Effects and Supplements: During GLP-1 receptor agonist clinical trials , the most commonly reported side effects were digestive issues. Probiotic pills with beneficial bacteria may help decrease symptoms of gastrointestinal side effects including nausea and diarrhea by restoring the balance of gut flora. A. Nausea: B. Diarrhea: It’s also important to know that probiotics can improve digestion and have a favorable effect on the balance of good bacteria in the stomach. i. Multiple Strains of Probiotics: Follow are the instructions on the packaging. ii. Pain in the Abdomen: iii. Overall Assistance with Digestion: Conclusion: Therefore, like it is often recommended with any new supplement, it is always wise to consult a doctor, especially if the patient is diabetic or has other chronic diseases that require they take other medications. It will be possible for them to ensure you that no harm comes with the vitamins or any other medication that you are currently taking.