Semaglutide has revolutionized the management of type 2 diabetes and obesity, offering significant benefits with regular use. Knowing the duration each vial lasts can help you maintain a seamless treatment schedule and maximize the medication’s effectiveness. Wondering how long does a vial of Semaglutide last?

A vial of Semaglutide lasts for up to 56 days after opening, provided it is stored at room temperature (up to 86°F or 30°C) or refrigerated between 36°F to 46°F (2°C to 8°C). Unopened vials should be refrigerated only and can be kept until their expiration date. If necessary, Wegovy can last 28 days if kept at room temperature. 

Dive into this comprehensive guide to learn how dosage, frequency, and proper storage determine how long a vial of Semaglutide will last. Get empowered with the knowledge to manage your treatment more effectively and maintain optimal health.

Factors Affecting Semaglutide Vial Longevity

1. Expiration Date and Manufacturer Guidelines

Semaglutide vials are labeled with an expiration date, which should be the first indicator of its shelf life. Unopened Semaglutide vials should not be used past this date. The manufacturers rigorously test the stability of the medication under various conditions to determine this date, ensuring the safety and effectiveness of the medication up to this point.

2. Storage Conditions

Improperly stored Semaglutide vials should be disposed of immediately. However, mind that Semaglutide injections can remain effective even if exposed to temperatures as high as 104°F (40°C) for up to three days. If your vials arrive warm, they are still safe to use, provided you transfer them to refrigerated conditions of 36-46°F (2-8°C) immediately upon receiving.

Opened Semaglutide vials last for up to 56 days if stored in the refrigerator between 2°C to 8°C or at room temperature below 30°C. Unopened vials should be refrigerated only and last till its expiry, except Wegovy which can be kept at room temperature if necessary and can last up to 28 days. It’s critical to keep the vial away from light and to avoid freezing it, as this can degrade its effectiveness.

3. Handling Practices

Proper handling of Semaglutide is crucial. Avoid shaking the vial vigorously as this can affect the medication’s integrity. Always use sterile needles and practice good hygiene when administering injections to prevent contamination. Improperly handled vials won’t last long.

4. Dosage Regimen

 The primary determinant of how long a vial of Semaglutide lasts is the prescribed dosage. Semaglutide is typically administered once a week, and the dosage can vary based on the specific needs of the patient.

Common starting doses for Semaglutide, for instance, are 0.25 mg per week for the first four weeks, followed by an increase to 0.5 mg. Depending on the therapeutic goals, the dose can be further increased to 1 mg (higher maintenance dose) or 2.4 mg per week (primarily for weight management under the brand name Wegovy)

Brand and Concentration	Dose	How long will one vial last?
Ozempic:1.5 mL vial contains 2 mg of Semaglutide	0.25 mg/ weekly	8 weeks
	0.5 mg/ weekly	4 weeks
Wegovy:4 mL vial contains 10 mg of Semaglutide	2.4 mg /weekly	4 weeks

5. Vial Concentration and Size

The concentration of Semaglutide in a vial also plays a critical role. For example, Ozempic is available in different strengths, such as 1.5 mg/1.5 mL (1 mg/mL) and 4 mg/3 mL (1.34 mg/mL). The size of the vial dictates how many doses can be extracted. Typically, a single vial of Ozempic contains multiple doses.

Take Away

For Semaglutide users, understanding the storage, handling, and expiration of the medication is key to ensuring its efficacy and safety. Always adhere to the storage instructions and use the medication within the recommended period after opening. If in doubt, consult your healthcare provider for guidance on how to manage your Semaglutide treatment effectively.

Frequently Asked Questions

How to properly store Semaglutide vial?

To properly store unopened Semaglutide vial, keep it in the refrigerator between 2°C to 8°C (36°F to 46°F). However, Wegovy can be stored outside at room temperature too, if necessary, for 28 days. Opened Semaglutide vials can be either kept at room temperature (below 30°C/86°F) or in the refrigerator lasting for 56 days after it is first used

Why is my Semiglutide vial solution discolored or cloudy?

A discolored or cloudy Semaglutide vial solution indicates potential degradation or contamination, which can occur due to improper storage, exposure to extreme temperatures, or the vial being past its expiration date. Do not use the solution and contact your healthcare provider or pharmacist for guidance and a replacement​

Can I use Semaglutide after it has expired?

No, it is not recommended to use Semaglutide after it has expired. Expired medications may lose potency, reducing their effectiveness, and could potentially cause adverse effects. Always check expiration dates and consult with a healthcare provider for safe and effective treatment options.

What to do if my Semaglutide is expired?

If your Semaglutide has expired, do not use it. Dispose of it according to local guidelines or return it to a pharmacy for safe disposal. Contact your healthcare provider to obtain a new prescription to ensure safe and effective treatment.

How to dispose of expired or improperly stored Semaglutide?

To dispose of expired or improperly stored Semaglutide, do not flush it down the toilet. Use local medication take-back programs or DEA-authorized collection sites if available. If these options are not accessible, mix the medication with an unappealing substance like coffee grounds or cat litter, seal it in a plastic bag, and dispose of it in your household trash.

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